Turns out these deep lesions regenerate rapidly without scarring. The spiny mouse achieves this regeneration feat thanks to its unique gene expression. The African spiny mouse is known for its ability to allow its skin to rip off its tail when being grabbed by predators because it can regenerate the missing bits. Two species of African spiny mouse have been caught at something no other mammal is known to do — completely regenerating damaged tissue … In this type, the lost part is regenerated via cellular proliferation, it is “newly created”. They have been used previously in tissue regeneration … Humans and other mammals are generally very limited when it comes to regeneration, but one mammal, the African spiny mouse, can heal wounds much … Combining developmental biology and modeling approaches, we have shown how hair follicle morphogenesis has been altered during the evolution of the spiny mouse … While vigorous movement could peel off up to 60 percent of the skin off the backs of these rodents, they could quickly heal these wounds and regrow spiny hairs that … Regeneration with cellular proliferation or “epimorphosis”. The team also found that the regeneration begins when the mouse forms a blastema, or a mass of cells which eventually grow into organs or body parts. by Keith Hautala (July 23, 2014) — University of Kentucky Biology Professor Ashley Seifert, whose research is focused on skin regeneration, is studying the African spiny mouse, a tiny mammal with some amazing regenerative abilities. For comparison, a house mouse’s skin is around 20 times stronger than a spiny mouse’s, and can absorb 77 times more energy before breaking. The African spiny mouse could become a new base for regenerative medicine research in mammals, said Ashley Seifert, a 36-year-old Department of Biology postdoctoral fellow at UF who worked on In reptiles we can find caudal autotomy in … But new research shows that tissue regeneration may not be … Given the general limits of mammals when it comes to regeneration, Seifert was fascinated by tales of the African spiny mouse. For most mammals, this would be a disaster. Video by UK Research Media. The African spiny mouse is native to the deserts of Africa, though it has since spread to southwest Asia and southern Europe. Video by Apnea. The African spiny mouse in the Acomys genus literally jumps out of its skin when grabbed, losing up to 60 percent of it. "What’s phenomenal is that they’re able to regenerate complex tissue structures," Seifert said. ... Caudal autotomy is found in many species of reptiles and in two species of spiny mouse of the genus Acomys.

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